Vildagliptin-Associated Bullous Pemphigoid: A Case Report

Roy, Debanjan; Gayen, Gunjan; Ara Begum, Sabnam; Ghosh, Sandip; Talukder, Sucheto; Sarkar, Arisha; Aich, Shritama

doi:10.18502/ijdo.v16i2.15711

Volume 16, Issue 2 (6-2024) IJDO 2024, 16(2): 122-126 | Back to browse issues page

‎ 10.18502/ijdo.v16i2.15711

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Roy D, Gayen G, Ara Begum S, Ghosh S, Talukder S, Sarkar A et al . Vildagliptin-Associated Bullous Pemphigoid: A Case Report. IJDO 2024; 16 (2) :122-126
URL: http://ijdo.ssu.ac.ir/article-1-874-en.html

Vildagliptin-Associated Bullous Pemphigoid: A Case Report

Debanjan Roy

, Shritama Aich ^*

Multidisciplinary Research Unit, R.G. Kar Medical College and Hospital, Kolkata, India.

Abstract: (235 Views)

Objective: Bullous pemphigoid is a rare autoimmune skin disorder characterized by blistering, urticarial lesions, which are sometimes associated with adverse drug reactions.
Vildagliptin is an oral anti-diabetic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme.
Materials and Methods: A 75-year-old female with a known case of type 2 Diabetes Mellitus, hypertension, and hypothyroidism for the last 10 years presented with pruriginous tense bullous skin lesions over her both palms and soles. There was no mucosal involvement. Further interrogation revealed that she started taking Vildagliptin 5 days ago which was prescribed due to high levels of post-prandial blood sugar level despite already intake of Glimepiride-4 mg and Metformin-3 gm.
Results: Vildagliptin was immediately advised to be stopped. She was treated with antihistamines, steroids, and conservative management which led to remission of the blisters.
Conclusion: Vildagliptin is the probable causative drug for developing bullous pemphigoid skin lesion which shows temporal association in this case as other concomitant drugs has no direct correlation. Therefore physicians must be aware of this rare life-threatening side effect of this medicine and advice patients to visit the hospital even the slightest cutaneous manifestation. Bullous pemphigoid can result in fatal life-threatening conditions if not treated early.

Keywords: Antibody engineering, Anti-VEGF-A, Bioinformatic, Binding affinity, Ranibizumab

Full-Text [PDF 538 kb] (212 Downloads)

Type of Study: Research | Subject: Special
Received: 2023/12/24 | Accepted: 2024/04/8 | Published: 2024/06/21

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